Dysfunction of Persisting ? Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis (Cell Reports)

Cohrs et al. utilize pancreas tissue slices of metabolically phenotyped subjects undergoing pancreatectomy to assess ? cell pathogenesis in type 2 diabetes development. They reveal ? cell dysfunction as an early hallmark in type 2 diabetes pathogenesis, manifesting as increased basal and missing first-phase insulin secretion, although ? cell mass is maintained.