T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development (Cell Reports)

Tcf1 promotes circulating memory T cell development and maintenance after systemic infections. Wu et al. show that Tcf1 inhibits CD103+ resident memory T cell development in influenza-virus-infected mice. Tcf1 may either promote or suppress memory T cell development, depending on systemic or mucosal infections.