Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism (Cell Reports)

Juxtaposed Nodal and BMP sources can induce the formation of a secondary axis in zebrafish embryos. Soh et al. analyze the input-output relationships in this patterning system and find that differential signaling kinetics lead to different activity ranges of Nodal and BMP, which are crucial for secondary axis formation.