Beta Cell Dedifferentiation Induced by IRE1? Deletion Prevents Type 1 Diabetes (Cell Metabolism)

Lee et al. show that ? cell-specific deletion of IRE1? in NOD mice prior to islet immune cell infiltration results in transient ? cell dedifferentiation. This cellular response alters the expression of ? cell autoantigens, immune inhibitory markers, MHC class I components, and the diabetogenic activity of T cells, leading to protection from type 1 diabetes.