Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis (Cell Metabolism)

Rohlenova et al. employ single-cell RNA sequencing to characterize angiogenic endothelial cells (ECs) in murine choroidal neovascularization and compare the phenotypes to ECs in tumor angiogenesis. Using integrated analysis, genome-scale metabolic modeling, and in vivo methods, they identify and validate SQLE and ALDH18A1 as metabolic angiogenic candidates.