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RSS FeedsMarine Drugs, Vol. 19, Pages 575: Saliniquinone Derivatives, Saliniquinones G`I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252 (Marine Drugs)

 
 

14 october 2021 16:07:54

 
Marine Drugs, Vol. 19, Pages 575: Saliniquinone Derivatives, Saliniquinones G`I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252 (Marine Drugs)
 


Four new anthraquinone derivatives, namely saliniquinones G`I (1`3) and heraclemycin E (4), were obtained from the Antarctic marine-derived actinomycete Nocardiopsis aegyptia HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds 1 and 2 showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative staphylococci (MRCNS), with MIC values ranging from 3.1 to 12.5 μM.


 
47 viewsCategory: Biochemistry, Molecular Biology, Pharmacology
 
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