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RSS FeedsIJMS, Vol. 22, Pages 11327: Cytokines as Biomarkers in Systemic Lupus Erythematosus: Value for Diagnosis and Drug Therapy (International Journal of Molecular Sciences)

 
 

20 october 2021 13:48:37

 
IJMS, Vol. 22, Pages 11327: Cytokines as Biomarkers in Systemic Lupus Erythematosus: Value for Diagnosis and Drug Therapy (International Journal of Molecular Sciences)
 


Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease. The disease is characterized by activation and dysregulation of both the innate and the adaptive immune systems. The autoimmune response targets self-molecules including cell nuclei, double stranded DNA and other intra and extracellular structures. Multiple susceptibility genes within the immune system have been identified, as well as disturbances in different immune pathways. SLE may affect different organs and organ systems, and organ involvement is diverse among individuals. A universal understanding of pathophysiological mechanism of the disease, as well as directed therapies, are still missing. Cytokines are immunomodulating molecules produced by cells of the immune system. Interferons (IFNs) are a broad group of cytokines, primarily produced by the innate immune system. The IFN system has been observed to be dysregulated in SLE, and therefore IFNs have been extensively studied with a hope to understand the disease mechanisms and identify novel targeted therapies. In several autoimmune diseases identification and subsequent blockade of specific cytokines has led to successful therapies, for example tumor necrosis factor-alpha (TNF-╬▒) inhibition in rheumatoid arthritis. Authors of this review have sought corresponding developments in SLE. In the current review, we cover the actual knowledge on IFNs and other studied cytokines as biomarkers and treatment targets in SLE.


 
58 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 22, Pages 11324: Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart (International Journal of Molecular Sciences)
IJMS, Vol. 22, Pages 11326: The Influence of Tea Tree Oil on Antifungal Activity and Pharmaceutical Characteristics of Pluronic®F-127 Gel Formulations with Ketoconazole (International Journal of Molecular Sciences)
 
 
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