Molecules, Vol. 27, Pages 722: Four New BenzoylamideDerivatives Isolated from the Seeds of Lepidium apetalumWilld. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1Pathway (Molecules)

Four new benzoylamide derivatives,lepidiumamide B–E (1–4), were isolated from the seeds of Lepidium apetalumWilld. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury.