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RSS FeedsMolecules, Vol. 27, Pages 736: General Method to Increase Carboxylic Acid Content on Nanodiamonds (Molecules)

 
 

23 january 2022 11:18:07

 
Molecules, Vol. 27, Pages 736: General Method to Increase Carboxylic Acid Content on Nanodiamonds (Molecules)
 


Carboxylic acid is a commonly utilized functional group for covalent surface conjugation of carbon nanoparticles that is typically generated by acid oxidation. However, acid oxidation generates additional oxygen containing groups, including epoxides, ketones, aldehydes, lactones, and alcohols. We present a method to specifically enrich the carboxylic acid content on fluorescent nanodiamond (FND) surfaces. Lithium aluminum hydride is used to reduce oxygen containing surface groups to alcohols. The alcohols are then converted to carboxylic acids through a rhodium (II) acetate catalyzed carbene insertion reaction with tert–butyl diazoacetate and subsequent ester cleavage with trifluoroacetic acid. This carboxylic acid enrichment process significantly enhanced nanodiamond homogeneity and improved the efficiency of functionalizing the FND surface. Biotin functionalized fluorescent nanodiamonds were demonstrated to be robust and stable single-molecule fluorescence and optical trapping probes.


 
86 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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