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RSS FeedsIJMS, Vol. 23, Pages 1323: Role of the mtDNA Mutations and Mitophagy in Inflammaging (International Journal of Molecular Sciences)

 
 

25 january 2022 07:37:22

 
IJMS, Vol. 23, Pages 1323: Role of the mtDNA Mutations and Mitophagy in Inflammaging (International Journal of Molecular Sciences)
 


Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connection between ROS-mediated mtDNA damage and mutations. In this review, we focus on the role of mitochondrial metabolism, mitochondria generated ROS, mitochondrial dynamics and mitophagy in normal ageing and pathological conditions, such as inflammation. Also, a chronic form of inflammation, which could change the long-term status of the immune system in an age-dependent way, is discussed. Finally, the role of inflammaging in the most common neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, is also discussed.


 
56 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 23, Pages 1322: Overexpression of Liriodendron tulipifera JAG Gene (LtuJAG) Changes Leaf Shapes in Transgenic Arabidopsis thaliana (International Journal of Molecular Sciences)
IJMS, Vol. 23, Pages 1324: A Polymorphism of Bactericidal/Permeability-Increasing Protein Affects Its Neutralization Efficiency towards Lipopolysaccharide (International Journal of Molecular Sciences)
 
 
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