Electrochemical vicinal oxyazidation of α-arylvinyl acetates (Beilstein Journal of Organic Chemistry)

Abstract α-Azidoketones are valuable and versatile building blocks in the synthesis of various bioactive small molecules. Herein, we describe an environmentally friendly and efficient electrochemical vicinal oxyazidation protocol of α-arylvinyl acetates to afford diverse α-azidoketones in good yields without the use of a stoichiometric amount of chemical oxidant. A range of functionality is shown to be compatible with this transformation, and further applications are demonstrated. Beilstein J. Org. Chem. 2022, 18, 1026–1031. doi:10.3762/bjoc.18.103