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RSS FeedsIJERPH, Vol. 19, Pages 15909: Baseline Proteinuria and Serum Creatinine Concentration as Clinical Predictors of Complete Renal Response in Patients with Lupus Nephritis: A Single-Center Experience (International Journal of Environmental Research and Public Health)

 
 

29 november 2022 11:16:15

 
IJERPH, Vol. 19, Pages 15909: Baseline Proteinuria and Serum Creatinine Concentration as Clinical Predictors of Complete Renal Response in Patients with Lupus Nephritis: A Single-Center Experience (International Journal of Environmental Research and Public Health)
 


The aim of the study was to identify robust predictors of complete renal response (CRR), within 36 months, in a single-center cohort of lupus nephritis (LN) patients. Patients with biopsy-confirmed LN who underwent kidney biopsy between 1 January 2010 and 31 December 2020 were included and followed up for at least 6 months. CRR was defined as a reduction of urinary protein-to-creatinine ratio (UPCR) below 0.50 g/g. We evaluated baseline demographic, laboratory, and biopsy characteristics as potential predictors of CRR, and selected the variables further evaluated with Kaplan–Meier curves and log-rank tests. The traits with a p-value < 0.1 were later tested with both uni- and multivariable Cox proportional hazard models. Our sample consisted of 57 patients (84% females, median age 32 years), out of which 63.2% reached CRR within 36 months. The initial UPCR and estimated glomerular filtration rate (eGFR) were the only variables in multivariable Cox regression model, which were selected through backward elimination, with a significance threshold <0.05 (HR = 0.77, p = 0.01 and HR = 1.02, p = 0.001). Our results confirmed the role of initial UPCR and serum creatinine concentration (sCr) as predictors of CRR in LN.


 
55 viewsCategory: Medicine, Pathology, Toxicology
 
IJERPH, Vol. 19, Pages 15912: Synthesis, Characterization and Decomposition of Potassium Jarosite for Adsorptive As(V) Removal in Contaminated Water: Preliminary Study (International Journal of Environmental Research and Public Health)
IJERPH, Vol. 19, Pages 15910: Detailed Geogenic Radon Potential Mapping Using Geospatial Analysis of Multiple Geo-Variables—A Case Study from a High-Risk Area in SE Ireland (International Journal of Environmental Research and Public Health)
 
 
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