Since its launch on 13 October 2017, the TROPOspheric Monitoring Instrument (TROPOMI) on board the Sentinel-5 Precursor (S5P) mission has been measuring the solar radiation backscattered by Earth’s atmosphere and surface. In this study, we evaluate the TROPOMI operational methane (CH4) and carbon monoxide (CO) products’ performance results covering about 3 years using the only two global Total Carbon Column Observing Network (TCCON) sites in China, i.e., the Hefei site and the Xianghe site. These two sites have recently joined the TCCON, and this study uses the both sites simultaneously to validate the TROPOMI products over China for the first time. We found that the systematic bias with rescaling between the TROPOMI CO products and the Hefei site is on average 1.78 ± 6.35 ppb or 1.18 ± 5.35%. The systematic bias with rescaling between the TROPOMI CO products and the Xianghe site is on average 5.33 ± 14.24 ppb or 3.85 ± 10.30%. Both the stations show a correlation above 0.9. The TROPOMI CO data are systematically higher than the two TCCON sites measurements in China. We found that the systematic bias with rescaling between the TROPOMI CH4 products and the Hefei site is on average −4.13 ± 11.65 ppb or −0.22 ± 0.62%. The systematic bias between the TROPOMI CH4 products and Xianghe site is on average −7.25 ± 10.72 ppb or −0.39 ± 0.57%. Both the stations show a correlation above 0.9. The TROPOMI CH4 data are systematically lower than the two TCCON sites measurements in China. We found that the bias between the TROPOMI and the two sites’ data as a function of the coincident radius around the two sites is mostly affected by localized emissions for both CO and CH4. We also observe a CO decreasing trend and a CH4 increasing trend in the year-to-year relative changes from 2019 to 2021. Validating against reference from Hefei and Xianghe TCCON site demonstrates the high quality of TROPOMI CO and CH4 data over China.