New-generation technologies on vehicles provide many advantages in terms of cost, time, and the environment in the transportation, logistics, freight, and delivery service sectors. This study aimed to measure the effect of using e-scooter vehicles in mail delivery on the energy cost and delivery time in Turkey. Considering the number of test drives in e-scooter applications of potential regions, the amount of energy consumption and driving time data were used. The number of test drives for each e-scooter was assumed as a package or postal delivery amount. The methodology of this study consisted of measuring the effect of input parameters on output variables using the linear response optimization regression method and minimizing the amount of energy consumed and delivery time. The nine input variables and two output variables based on the test drive were analyzed in this study. The distance to the delivery address, region where the delivery address was located, and temperature were found to be statistically significant predictors of the amount of energy required for delivery. The statistical significance levels of time zone, distance, temperature, rainfall, and region factors were calculated as 0.053, 0.001, 0.0033, 0.044, and 0.042, respectively. Driver age, data time zone, distance, wind speed, and delivery region factors affected the time required for delivery with an e-scooter. The statistical significance levels of these factors were calculated as 0.02, 0.001, 0.001, 0.043, and 0.001, respectively. Additionally, N (p; 0.042), NE (p; 0.030), and W (p; 0.057) wind directions directly influenced the delivery time. SE (p; 0.017) was the only wind direction that statistically significantly affected energy consumption. The objective functions were estimated by calculating the optimum values of the input parameters for the minimum energy consumption and delivery time. The optimum values of both input and output variables were calculated based on the desirability values of the optimization models, which were in the optimum solution set. The average data of the optimum values of the objective functions were computed as 2.83 for the number of tests and TRY 0.021 (per 0.098 km) for the energy cost required for delivery. The necessity of using e-scooters, which are more environmentally friendly, economical, and time-saving than traditional delivery vehicles, in postal delivery service is among the prominent suggestions of this study.