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RSS FeedsMolecules, Vol. 28, Pages 4518: Polyamine–Drug Conjugates: Do They Boost Drug Activity? (Molecules)


2 june 2023 09:43:08

Molecules, Vol. 28, Pages 4518: Polyamine–Drug Conjugates: Do They Boost Drug Activity? (Molecules)

Over the past two decades, the strategy of conjugating polyamine tails with bioactive molecules such as anticancer and antimicrobial agents, as well as antioxidant and neuroprotective scaffolds, has been widely exploited to enhance their pharmacological profile. Polyamine transport is elevated in many pathological conditions, suggesting that the polyamine portion could improve cellular and subcellular uptake of the conjugate via the polyamine transporter system. In this review, we have presented a glimpse on the polyamine conjugate scenario, classified by therapeutic area, of the last decade with the aim of highlighting achievements and fostering future developments.

64 viewsCategory: Biochemistry, Chemistry, Molecular Biology
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