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RSS FeedsIJMS, Vol. 24, Pages 12978: Parp Inhibitors and Radiotherapy: A New Combination for Prostate Cancer (Systematic Review) (International Journal of Molecular Sciences)

 
 

19 august 2023 12:49:11

 
IJMS, Vol. 24, Pages 12978: Parp Inhibitors and Radiotherapy: A New Combination for Prostate Cancer (Systematic Review) (International Journal of Molecular Sciences)
 


PARPi, in combination with ionizing radiation, has demonstrated the ability to enhance cellular radiosensitivity in different tumors. The rationale is that the exposure to radiation leads to both physical and biochemical damage to DNA, prompting cells to initiate three primary mechanisms for DNA repair. Two double-stranded DNA breaks (DSB) repair pathways: (1) non-homologous end-joining (NHEJ) and (2) homologous recombination (HR); and (3) a single-stranded DNA break (SSB) repair pathway (base excision repair, BER). In this scenario, PARPi can serve as radiosensitizers by leveraging the BER pathway. This mechanism heightens the likelihood of replication forks collapsing, consequently leading to the formation of persistent DSBs. Together, the combination of PARPi and radiotherapy is a potent oncological strategy. This combination has proven its efficacy in different tumors. However, in prostate cancer, there are only preclinical studies to support it and, recently, an ongoing clinical trial. The objective of this paper is to perform a review of the current evidence regarding the use of PARPi and radiotherapy (RT) in PCa and to give future insight on this topic.


 
1868 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 24, Pages 12972: Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model (International Journal of Molecular Sciences)
IJMS, Vol. 24, Pages 12980: Structure-Based Modeling of Sigma 1 Receptor Interactions with Ligands and Cholesterol and Implications for Its Biological Function (International Journal of Molecular Sciences)
 
 
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