An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity (Neuron)

AMPA-receptors are key players of excitatory neurotransmission and learning. Schwenk et al. show that assembly of native AMPARs in the ER occurs in discrete steps determined by ER-resident interactors; disturbance of this assembly phenocopies the severe intellectual disability in patients.