High-Throughput Single-Cell Sequencing with Linear Amplification (Molecular Cell)

Yin et al. developed sci-L3, which combines a scalable single-cell barcoding scheme with linear amplification. The method flexibly enables single-cell whole-genome sequencing, targeted DNA sequencing, or concurrent profiling of the genome and transcriptome. With sci-L3, the authors discovered mitotic-like whole-genome chromosome segregation in male mouse meiosis I.