F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis (Developmental Cell)

Mitotic rounding, which is essential for accurate spindle positioning, is controlled by the sub-membranous cortical actin network. Using proteomics, Serres et al. identify the intermediate filament vimentin as a key regulator of the mitotic cortex. Vimentin forms a sub-cortical layer in mitosis and controls actin cortex organization and mechanics.