Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance (Cell Reports)

Sullivan et al. show that while many factors and cytokines contribute to primary immunosuppression, EV-associated IL-35 uniquely promotes `infectious` tolerance not only by inducing IL-35 production in non-Treg cells but also by causing an immunosuppressive phenotype in EV-acquiring T and B cells, leading to secondary suppression of immune responses.