Distinct Dorsal and Ventral Hippocampal CA3 Outputs Govern Contextual Fear Discrimination (Cell Reports)

Besnard et al. show that dorsal and ventral hippocampal CA3 projections to CA1 and dorsolateral septum (DLS) play distinct roles in calibration of contextual fear discrimination. DLS parvalbumin inhibitory neurons receive monosynaptic dorsal CA3 inputs and modulate fear responses in a context-specific manner.