Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress (Cell Reports)

The formation of aggregate foci upon heat shock is often considered a hallmark of toxicity. Cabrera et al. show that misfolded substrates are sequestered into protein aggregate centers (PACs) in a chaperone-mediated adaptation strategy. Proteins at PACs are protected from degradation, and they can refold after heat stress.