The Antimalarial Natural Product Salinipostin A Identifies Essential ?/? Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites (Cell Chemical Biology)

Using a probe analog of the antimalarial natural product Sal A, Yoo et al. identify its targets as multiple essential serine hydrolases, including a homolog of human monoacylglycerol lipase. Because parasites were unable to generate robust in vitro resistance to Sal A, these enzymes represent promising targets for antimalarial drugs.