Cell Biology
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21 february 2020 02:03:02 |
| Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression (Molecular Cell) |
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Tweet H2AK119ub1 deposition acts as a central hub for mounting PcG repressive machineries. Tamburri et al. dissected the role of H2AK119ub1 in stabilizing PRC2 and canonical PRC1 activities, highlighting how the deposition of H2AK119ub1, but not the structural assembly of PRC1 complexes, is essential to maintain transcriptional repression. |
| 147 viewsCategory: Molecular Biology, Cell Biology |
 Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos (Molecular Cell)PRC1 Catalytic Activity Is Central to Polycomb System Function (Molecular Cell) 
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