PRC1 Catalytic Activity Is Central to Polycomb System Function (Molecular Cell)

In this study, Blackledge et al. generate a conditional catalytic point mutant system to test the contribution of PRC1 catalytic activity to the Polycomb repressive system. They reveal that PRC1 catalytic activity is essential for Polycomb chromatin domain formation, long-range chromatin interactions between Polycomb target sites, and Polycomb-mediated gene repression.