Re: Karl H. Tully, David-Dan Nguyen, Peter Herzog, et al. Risk of Dementia and Depression in Young and Middle-aged Men Presenting with Nonmetastatic Prostate Cancer Treated with Androgen Deprivation Therapy. Eur Urol Oncol. In press. http://dx.doi.org/10.1016/j.euo.2019.08.003 (European Urology Oncology)

We read the very interesting paper by Tully et al [1] regarding the risk of dementia and depression among young and middle-aged men presenting with nonmetastatic prostate cancer treated with androgen deprivation therapy (ADT). Their study included men aged 40-64 yr with nonmetastatic prostate cancer and the study results identify ADT use as a risk factor for dementia and depression. These findings are very important and underline some of the possible side effects of ADT. It is well described that ADT resulting in testosterone levels of