Cohesin Removal Reprograms Gene Expression upon Mitotic Entry (Molecular Cell)

During mitosis, chromosomes condense and transcription is silenced to facilitate chromosome segregation. However, centromeres are transcribed during mitosis. Perea-Resa et al. find that mitotic cohesin regulation is important for mitotic transcriptional silencing, mitotic centromere transcription, and transcriptional restart in G1. Coupled cohesin/transcription dynamics ensures chromosome segregation and gene expression reprograming across mitosis.