Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing (Developmental Cell)

Using single-nucleus RNA sequencing, Cui et al. identified a unique immature cardiomyocyte population associated with heart regeneration in newborn mice. The NFYa and NFE2L1 factors are activated in these cardiomyocytes after injury and can confer protection against ischemic injury in mature mouse hearts that are otherwise non-regenerative.