Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons (Cell Metabolism)

Dietary triglycerides (TGs) can gate dopamine receptor type 2 (DRD2)-expressing neurons` activity and dopamine-dependent behaviors. These results highlight a new physiological mechanism by which nutritional inputs can directly tune reward-associated behaviors and provide a new basis by which energy-rich diets may lead to (mal)adaptations in brain circuits that underlie compulsive behavior.