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RSS FeedsIJMS, Vol. 23, Pages 1326: Improving Protein Quantity and Quality—The Next Level of Plant Molecular Farming (International Journal of Molecular Sciences)

 
 

25 january 2022 08:38:45

 
IJMS, Vol. 23, Pages 1326: Improving Protein Quantity and Quality—The Next Level of Plant Molecular Farming (International Journal of Molecular Sciences)
 


Plants offer several unique advantages in the production of recombinant pharmaceuticals for humans and animals. Although numerous recombinant proteins have been expressed in plants, only a small fraction have been successfully put into use. The hugely distinct expression systems between plant and animal cells frequently cause insufficient yield of the recombinant proteins with poor or undesired activity. To overcome the issues that greatly constrain the development of plant-produced pharmaceuticals, great efforts have been made to improve expression systems and develop alternative strategies to increase both the quantity and quality of the recombinant proteins. Recent technological revolutions, such as targeted genome editing, deconstructed vectors, virus-like particles, and humanized glycosylation, have led to great advances in plant molecular farming to meet the industrial manufacturing and clinical application standards. In this review, we discuss the technological advances made in various plant expression platforms, with special focus on the upstream designs and milestone achievements in improving the yield and glycosylation of the plant-produced pharmaceutical proteins.


 
101 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 23, Pages 1324: A Polymorphism of Bactericidal/Permeability-Increasing Protein Affects Its Neutralization Efficiency towards Lipopolysaccharide (International Journal of Molecular Sciences)
IJMS, Vol. 23, Pages 1325: Blockade of β2-Adrenergic Receptor Reduces Inflammation and Oxidative Stress in Clear Cell Renal Cell Carcinoma (International Journal of Molecular Sciences)
 
 
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