Molecular Architecture of a Network of Potential Intracellular EGFR Modulators: ARNO, CaM, Phospholipids, and the Juxtamembrane Segment (Structure)

Interactions with the intracellular juxtamembrane (JM) segment of the membrane spanning epidermal growth factor receptor (EGFR) can modulate its vital signaling. Viegas et al. unravel an interaction network comprising lipids, proteins, as well as individual cofactors, and characterize the molecular mechanisms of the respective interactions with EGFR`s JM segment.