A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary (Molecular Cell)

Galupa et al. uncover elements important for Xist regulation in its neighboring TAD and reveal that these elements can influence gene regulation both within and between topological domains. These findings, in a context where dynamic, developmental expression is necessary, challenge current models for TAD-based gene-regulatory landscapes.