Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation (Cell Reports)

Pore-forming agents like bacterial toxins or complement kill cells by attacking the plasma membrane. Wu et al. show that the calcium-activated lipid scramblase TMEM16F promotes plasma membrane repair after pore formation by enhancing membrane fluidity and facilitating release of extracellular vesicles containing damaged membranes.