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RSS FeedsStructural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement (Cell Reports)

 
 

28 january 2020 20:02:42

 
Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement (Cell Reports)
 
CLCA1 is a secreted potentiator of the calcium-activated chloride channel TMEM16A. Berry et al. report the structure and biophysical analysis of the human CLCA1 VWA domain, which binds to and potentiates TMEM16A. Their results suggest how the VWA MIDAS engages TMEM16A.


 
177 viewsCategory: Cell Biology
 
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